Insulin resistance and PCOS: chicken or egg? Novel associations are underlined. Li J, Eriksson M, Czene K, Hall P, Rodriguez-Wallberg KA. A full list of FinnGen contributors can be found in Supplementary Data. Reference-based phasing using the Haplotype Reference Consortium panel. When adding BMI as a covariate only one of the novel variants remained genome-wide significant in the meta-analysis (the EstBB lead signal in CHEK2 rs182075939, P = 1.91016, OR = 1.74 [1.52.01]) possibly owing to reduced sample size. Irrigation District 1. Included adjustments were age, genotyping batches and the first 10 PCs. Considering the complex nature of the syndrome, it is likely that both genetic and environmental factors contribute to its development (Abbott et al., 2019; Koivuaho et al., 2019; Moghetti and Tosi, 2021). Functional characterization of this locus revealed a frameshift variant, c.1100delC (rs555607708, P = 1.68109, OR = 13.46 [5.6831.89]) in CHEK2, with a high LD (r2 = 0.95) with the lead variant. endobj In this analysis, the FinnGen lead variant rs145598156 remained genome-wide significant (P = 4.5108, OR = 13.5 [5.3534.38]) (Table I and Supplementary Fig. A rc adi W te Comp ny . Spokane Valley WA 99016 A genome-wide association study of polycystic ovary syndrome identified from electronic health records. An interaction between BMI and PCOS-associated variants has previously been suggested (Wojciechowski et al., 2012), and interestingly, the c.1100delC variant in CHEK2 has recently been shown to predispose particularly obese carriers to the development of breast cancer (Greville-Heygate et al., 2020). Consolidation Irrigation District Copyright 2023 - All Rights Reserved. 100 Coop 2. The average effect sizes of the novel alleles described in chromosome 22 (OR = 1.693.01) (Table I) were higher than the effects observed for alleles associated with PCOS in the rest of the common variants described (OR = 1.061.40), which could be explained by the often-observed inverse relationship between allele frequency and effect size (Manolio et al., 2009). Also, BMI data were not available for all (63% for FinnGen, 76% for EstBB), and the biobank setting limited the accessibility of PCOS phenotypes and laboratory values. Common diseases as determinants of menopausal age. Hassayampa Water Coop 26. Suite C Leveraging Northern European population history: novel low-frequency % 120 N Greenacres Road This can happen if the system loses pressure. Kilpivaara O, Vahteristo P, Falck J, Syrjkoski K, Eerola H, Easton D, Bartkova J, Lukas J, Heikkil P, Aittomki K et al. The interplay of past demographic events may result in regionally varying genetic architectures for medical conditions (Peltonen et al., 2000; Martin et al., 2018). Correspondence address. Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA. An integrated map of genetic variation from 1,092 human genomes, Hyperandrogenic origins of polycystic ovary syndromeimplications for pathophysiology and therapy, Introduction: determinants of polycystic ovary syndrome, Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland. Nevertheless, three recent studies utilizing a Mendelian randomization approach have suggested a modest but significant causal effect between PCOS and breast cancer (Wu et al., 2020; Wen et al., 2021; Zhu et al., 2021). RCW 87.03.535: Consolidation of irrigation districtsProceedings for The lead variant rs145598156 (P = 1.71011, odds ratio (OR) = 11.63 [5.6923.77]) is located in an intronic region 11 kb from the transcription start site (TSS) of ZNFR3 (Table I and Fig. sharing sensitive information, make sure youre on a federal East Spokane Water District No. Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland. Court Addresses Scope Of Materials That Must Be Included In - Kronick 1000 Genomes Project Consortium 813707 (N.P.-G., T.L. A specific association between menopause-delaying alleles and PCOS has also been previously demonstrated (Day et al., 2015). A validation GWAS was performed in the EstBB, including 2812 cases and 89230 controls. and T.P. Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Genome-wide significant variants in FinnGen data are denoted with purple circles; Estonian Biobank-specific variants are not circled. Genotypes were imputed with Beagle 4.1 using the SiSu v3 imputation reference panel, which consisted of 3775 individuals of Finnish ancestry with sequenced whole genomes. Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ; International PCOS Network. The Helsinki and Uusimaa District is the largest Finnish Red Cross District with 20,600 members and . CID is responsible for local, state and federal regulatory compliance and reporting. Testing is due annually, and failure to provide acceptable test results by the due date may result in fines. The https:// ensures that you are connecting to the We identified three novel genome-wide significant associations with PCOS, with two putative independent causal variants in the checkpoint kinase 2 (CHEK2) gene and a third in myosin X (MYO10). Association analysis was carried out using SAIGE (v0.38) software to implement a mixed logistic regression model with a year of birth and 10 PCs as covariates in step I. As a library, NLM provides access to scientific literature. Although a metabolic link between MYO10 and PCOS seems likely, further research is needed to characterize the role of MYO10 in PCOS. Please note the holidays that the office is closed: New Year's Day Memorial Day Independence Day Labor Day Veteran's Day Thanksgiving Day and the Friday after However, these common genetic variants explain only around 10% of the heritability (Azziz, 2016). The general service areas are from Flora Road east to the Idaho border, excluding Liberty Lake and Newman Lake. The District currently serves more than 600 customers. The parties ultimately agreed the administrative record would be prepared jointly. Finnish Institute for Health and Welfare, Helsinki, Finland. Hillander-C Irrigation And Drainage District Consolidated Irrigation District No. 14 - Washington stream CID plays an active role in managing our groundwater basin; overseeing pumping, recharge and monitoring. 2022 CCR Water Quality Report, 1521 N. Argonne Rd. Up to 12,000 cubic feet at $3.50/1,000 cubic feet. Ovulatory dysfunction often subsides with age; however, women with PCOS still display higher AMH and later onset of menopause (Piltonen et al., 2005; Li et al., 2016; de Ziegler et al., 2018; Minooee et al., 2018; Forslund et al., 2019). Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland. We also replicated four previous reported associations near the genes Erb-B2 Receptor Tyrosine Kinase 4 (ERBB4), DENN Domain Containing 1A (DENND1A), FSH Subunit Beta (FSHB) and Zinc Finger And BTB Domain Containing 16 (ZBTB16). Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland. The y axis represents log(two-sided P-values) for the associations of variants with PCOS from meta-analysis, using an inverse-variance weighted fixed-effects model. endobj Zhang Y, Ho K, Keaton JM, Hartzel DN, Day F, Justice AE, Josyula NS, Pendergrass SA, Actkins K, Davis LK et al. Inclusion in an NLM database does not imply endorsement of, or agreement with, Riikka K Arffman, ), 321763 (T.P. Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies, Polycystic ovary syndrome and breast cancer subtypes: a Mendelian randomization study, https://creativecommons.org/licenses/by-nc/4.0/, 1000 Genomes Project Consortium et al., 2012, https://dx.doi.org/10.17504/protocols.io.xbgfijw, https://www.well.ox.ac.uk/~wrayner/strand/, https://github.com/eQTL-Catalogue/colocalisation. 8 0 obj To find your division on the new map, click on the image below which will take you to our Find your Division tool. Consolidated Irrigation District No. the contents by NLM or the National Institutes of Health. Polycystic ovary syndrome (PCOS) is a common, multifaceted endocrine disorder. Bill Stretch Manager Fresno Irrigation District 2907 S. Maple Avenue Fresno, CA 93725 . All biobank participants have signed a broad informed consent form. V.K. CID provides irrigation water deliveries, water right protection, groundwater management and rechar Consolidated Irrigation District | Selma CA Finally, we performed a joint meta-analysis of 3609 cases and 229788 controls from both cohorts. PDF Groundwater Management Plans (AB3030 / SB1938) and Groundwater Quality The Central Kings GSAs jurisdiction includes portions of the Kings Subbasin excluding the service areas of South Kings GSA. and N.P.-G. carried out the research and investigation process, manuscript writing and data visualization. The role of polygenic risk and susceptibility genes in breast cancer over the course of life. The validity of the PCOS diagnosis is also supported by the fact that we were able to replicate four previously reported signals, ERBB4, DENND1A, FSHB and ZBTB16. matters concerning the Hospital District of Helsinki and Uusimaa (HUS) to the Market Court. Rates - Consolidated Irrigation District No. 19 ), Novo Nordisk Foundation grant NNF17OC0026062 (J.K.), the Sigrid Juselius Foundation project grants (T.L., J.K., T.P. ), 297338 (J.K.), 307247 (J.K.), 344695 (H.L. 2255 Chandler Ave | PO Box 209 Selma | Phone: 559-896-1660 | Fax: 559-896-8488. There are currently no studies evaluating the pathogenic role of c.1100delC or I157T in Estonians, which underlines the need for further research assessing the impact of these variants in this population. (509) 924-3656 The register-based approach is also a limiting factor, as the health register-based prevalence of PCOS is very low in our study populations (0.57% for FinnGen and 3.15% for the EstBB), plausibly reflecting underdiagnosis of the syndrome. Formatting and preparation of the FinnGen association data for downstream analysis were managed with workflow management software STAPLER (Tyrmi, 2018). 19, Board of Directors Meeting Thus, the present study reinforces the links between PCOS, abnormal follicle development and high levels of AMH. Furthermore, as several studies suggest a causal role for obesity in PCOS (Legro, 2012; Brower et al., 2019; Zhao et al., 2020), we examined the influence of BMI on the detected associations with PCOS. Forest plot of effect estimates for the seven lead variants associated with PCOS. Natlia Pujol-Gualdo, <> In FinnGen, cases of PCOS were defined as women with a record of the following International Classification of Diseases (ICD)-10 code E28.2, ICD-9 code 256.4, or ICD-8 code 256.90. Consolidated Irrigation District 2255 Chandler St. Selma, CA 93662 . In 2014, Governor Brown signed into law the Sustainable Groundwater Management Act (SGMA), which provides local agencies with authority to manage groundwater basins in a sustainable manner. The Coordinating Ethics Committee of the Hospital District of Helsinki and Uusimaa (HUS) approved the FinnGen study protocol (Nr HUS/990/2017). Regional plot for the Estonian Biobank lead variant in the same locus 22q11 before and after conditional analysis with linked missense variant (rs17879961) are shown in (C) and (D). CID invests a significant amount of resources annually for the oversight, registration and protection of local water rights. We lifted the GWAS summary statistics over to the hg38 build to match the eQTL catalogue and convert the summary statistics to variant call format. CONSOLIDATED IRRIGATION DISTRICT No. 19 Notably, the heritability of PCOS is estimated to be around 70% (Vink et al., 2006; Risal et al., 2019). Labor Day Veterans Day Thanksgiving Day and the Friday after Pre-phasing was conducted using Eagle v2.3 software (Loh et al., 2016) (number of conditioning haplotypes Eagle2 uses when phasing each sample was set to: Kpbwt = 20000), and imputation was carried out using Beagle 4.1 with effective population size ne = 20000. PDF Redistricting Preliminary Options Overview The authors declare no conflicts of interest. Risal S, Pei Y, Lu H, Manti M, Fornes R, Pui HP, Zhao Z, Massart J, Ohlsson C, Lindgren E et al. Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland. The November Board Meeting will be moved to the 3rd Wednesday on November 16th, 2022 at 7:00 P.M. Women with PCOS also have an increased risk for endometrial cancer; however, the majority of studies do not indicate a higher susceptibility to other types of cancer (Dumesic and Lobo, 2013; Barry et al., 2014; Gottschau et al., 2015; Ding et al., 2018). PCOS is a common, complex disorder with unknown aetiology. 7 0 obj Pay Your Bill Online * New Customers Backflow Testing Water Saving Tips * When paying your bill online please enter your account number only - if you enter your address it confuses the Invoice Cloud system. Co. 24. Checkpoint kinase 2 variants described. Samples were genotyped and PLINK format files were created using Illumina GenomeStudio v2.0.4. CID No. 19, located in Greenacres in the Spokane Valley, began operations in 1966. Meijers-Heijboer H, van den Ouweland A, Klijn J, Wasielewski M, de Snoo A, Oldenburg R, Hollestelle A, Houben M, Crepin E, van Veghel-Plandsoen M et al. Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations. Our study also detected the previously reported associations with PCOS for ERBB4, DENND1A, FSHB and ZBTB16. March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. Consolidated Irrigation District No. Up to 8,000 cubic feet at $3.50/1,000 cubic feet. 4). Benner C, Havulinna AS, Jrvelin MR, Salomaa V, Ripatti S, Pirinen M. Prospects of fine-mapping trait-associated genomic regions by using summary statistics from genome-wide association studies. The mutational constraint spectrum quantified from variation in 141,456 humans. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Department of Clinical Genetics, Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland. Ollila MM, Piltonen T, Puukka K, Ruokonen A, Jarvelin MR, Tapanainen JS, Franks S, Morin-Papunen L. Weight gain and dyslipidemia in early adulthood associate with polycystic ovary syndrome: prospective cohort study, Use of population isolates for mapping complex traits. endobj Genotype calls were made using GenCall or zCall (Goldstein et al., 2012) for Illumina and the AxiomGT1 algorithm for Affymetrix data. Zhao Y, Xu Y, Wang X, Xu L, Chen J, Gao C, Wu C, Pan D, Zhang Q, Zhou J et al. The GWAS meta-analysis summary statistics that support the findings of this study are available for download from the GWAS Catalog at ebi.ac.uk/gwas/ with accession ID numbers GCST90044902 and GCST90044903. The Consolidated Irrigation District ("CID") made a Public Records Act request for certain public records in City's possession regarding the CEQA proceedings. The meetings will be held on: Please complete our Prop 218 Support Form to add your name to our list of Supporters: Consolidation Irrigation District Copyright 2023 - All Rights Reserved. Genotypes with a HardyWeinberg Equilibrium (HWE) P-value below 1e-6, minor allele count <3, and genotyping success rate <98% were removed. This included a total of 2812 cases and 89230 controls. FinnGen data freeze release 6 (R6) combines the genomic information of 141355 women (6% of the female Finnish population). This study also presents an interesting novel association in an intronic region of MYO10. ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4); DENND1A (DENN Domain Containing 1A); FSHB (FSH Subunit Beta); ZBTB16 (Zinc Finger And BTB Domain); MYO10 (myosin X); CHEK2 (Checkpoint kinase 2). Under state law, divisions of special districts should: The Board of Directors worked with census data and outside consultants to assess Consolidated Irrigation Districts population and communities of related interests to develop preliminary options for the five divisions of Consolidated Irrigation District by February 2022. SELAH-MOXEE IRRIGATION DISTRICT PO Box 166, 113 E. Moxee Avenue Moxee, WA 98936 Phone: (509) 469-0449 Fax: (509) 469-0489 Email: smidistrict@qwestoffice.net The horizontal dashed line represents the threshold for genome-wide significance. A total of 2812 cases and 89230 controls were included in the analyses. Muranen TA, Blomqvist C, Drk T, Jakubowska A, Heikkil P, Fagerholm R, Greco D, Aittomki K, Bojesen SE, Shah M et al. When also adjusting the GWAS for BMI, the EstBB lead variant rs182075939 remained genome-wide significant (P = 4.61011, OR = 1.68 [1.441.96]) (Table I and Supplementary Fig. 2019 CCR Water Quality Report ), the Estonian Research Council grant (PRG687, T.L. Spokane Valley, WA 99212 The novel gene candidates in the six genome-wide significant loci are highlighted in bold. Bethesda, MD 20894, Web Policies Repair And Replacement CID's infrastructure dates back to the late 1800's and therefore requires investment in repairing and replacing these vital resources. Finnish Institute for Health and Welfare, Helsinki, Finland. Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Haplotype sharing provides insights into fine-scale population history and disease in Finland. Day F, Karaderi T, Jones MR, Meun C, He C, Drong A, Kraft P, Lin N, Huang H, Broer L et al. Financial recourse when hiring Consolidated Irrigation District 19. Since 1939 Consolidated Irrigation District No. 2A). ), 297338 (J.K.), 307247 (J.K.), 344695 (H.L. Read more. Fredonia Consolidated Irrigation and Mfg. 2B). The site is secure. <> About the assessment audit This report contains the results of our independent audit of Consolidated Irrigation District No. Read more. ), 321763 (T.P. Member Purveyors - Spokane Aquifer Joint Board . This analysis included 2619 cases and 160321 controls, and a total of 24461102 genetic markers were analyzed. Genetic variation in MYO10 has previously been linked to type 2 diabetes (Salonen et al., 2007) and traits of metabolic syndrome (Zhang et al., 2013). Home; Your Account. Additionally, we reran the association analyses including BMI as a covariate, with 2169 cases and 160321 controls from both cohorts. <> In addition to the reproductive features, PCOS is also characterized by metabolic disturbances such as obesity, insulin resistance and dyslipidemia (Ollila et al., 2016; Lim et al., 2019; Barber and Franks, 2021). Although only covering three percent (9,440 km 2) of our national land area, our Region is home to around 1.7 million inhabitants, which is about a third of the country's total population. Conditioning the discovery analysis on I157T had a minimal effect on the genome-wide significant associations in this locus, with a P-value of 9.091012 for the lead variant rs145598156. All EstBB participants were genotyped using Illumina GSAv1.0, GSAv2.0 and GSAv2.0_EST arrays at the Core Genotyping Lab of the Institute of Genomics, University of Tartu. Center for Life Course Health Research, Faculty of Medicine, Aapistie 5A, PO Box 5000, 90014 University of Oulu, Oulu, Finland. CONSOLIDATED IRRIGATION DISTRICT No. Individuals with PCOS were identified using the ICD-10 code E28.2, and all of the female biobank participants without this diagnosis served as controls. %PDF-1.5 Ruth KS, Day FR, Hussain J, Martnez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins J et al. Lim ET, Wrtz P, Havulinna AS, Palta P, Tukiainen T, Rehnstrm K, Esko T, Mgi R, Inouye M, Lappalainen T et al. Samples were pre-phased with Eagle 2.3.5 (Loh et al., 2016) using 20000 conditioning haplotypes. Join an in-person public hearing at the Consolidated Irrigation District Offices Wednesday, March 9 at 1pm Email info@cidwater.com Call (559) 896-1660 and ask . Sprinkler systems are required to have a backflow prevention device. Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland. In conclusion, we identified two rare population-enriched variants located in CHEK2 that are significantly associated with PCOS. Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alfldi J, Wang Q, Collins RL, Laricchia KM, Ganna A, Birnbaum DP et al. Consolidated Irrigation District Company Profile | Selma, CA | Competitors, Financials & Contacts - Dun & Bradstreet The general service areas are from Flora Road east to the Idaho border, excluding Liberty Lake and Newman Lake. Independent FinnGen and Estonian Biobank (EstBB) GWAS associations overlapping the checkpoint kinase 2 (CHEK2) gene are plotted on a single LocusZooms figure. Chen ZJ, Zhao H, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J et al. Thus, it has been suggested that rare variants with larger effect sizes may contribute to the heritability of PCOS (Dapas and Dunaif, 2020). Patient survival and tumor characteristics associated with CHEK2:p.I157Tfindings from the Breast Cancer Association Consortium. The third novel association is a common variant near MYO10 (rs9312937, P = 1.7 108, OR = 1.16 [1.101.23], MAF = 0.44). Backflow Testing - Consolidated Irrigation District No. 19 A final plan was submitted to the Board of Directors for a vote of approval at their meeting on March 9, 2022. The Market Court imposed a total penalty payment of EUR 50.000 on HUS regarding the direct procurement of waste disposal bags and tissue paper products.14 The next two decisions on the direct Fresno County is principal for Consolidated, Orange Cove and Hills Valley.Kings County is principal for Corcoran.Tulare County is principal for Alta and Delano-Earlimart. bstretch@fresnoirrigation.com. New Construction - Consolidated Irrigation District No. 19 Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes. Heritability of polycystic ovary syndrome in a Dutch twin-family study. Patients and control subjects in FinnGen provided informed consent for biobank research based on the Finnish Biobank Act. The meta-analysis also revealed three more variants associating with PCOS, in addition to the three detected in the FinnGen and EstBB GWAS separately (Table I and Supplementary Fig. Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland. Variant positions (BP) are according to GRCh37/hg19. Genome-wide association studies (GWAS) from the Finnish dataset (A), GWAS from Estonian dataset (B) and joint GWAS meta-analysis of polycystic ovary syndrome (PCOS) (C). 2021 CCR Water Quality Report CHEK2 rs555607708 (c.1100delC), the likely association-driving variant in FinnGen, is a Finnish-enriched variant with a 3.7-fold enrichment compared to non-Finnish, non-Estonian Europeans and with an enrichment of 1.7 compared to Estonians (Mars et al., 2020). 19, General Notes for Water System Construction, Combination Fire Line Commercial Water Service. Loh PR, Danecek P, Palamara PF, Fuchsberger C, A Reshef Y, K Finucane H, Schoenherr S, Forer L, McCarthy S, Abecasis GR et al. Koivuaho E, Laru J, Ojaniemi M, Puukka K, Kettunen J, Tapanainen JS, Franks S, Jrvelin M-R, Morin-Papunen L, Sebert S et al. Goldstein JI, Crenshaw A, Carey J, Grant GB, Maguire J, Fromer M, ODushlaine C, Moran JL, Chambert K, Stevens C et al. Lim SS, Kakoly NS, Tan JWJ, Fitzgerald G, Bahri Khomami M, Joham AE, Cooray SD, Misso ML, Norman RJ, Harrison CL et al. Interestingly, the identified variant seems to be associated with the age at menarche (Kichaev et al., 2019), indicating a reproductive function for MYO10. Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland. and transmitted securely. Gene-based analysis was also performed in this platform using MAGMA (de Leeuw et al., 2015). Sample genotyping in FinnGen was performed using Illumina and Affymetrix arrays (Illumina Inc., San Diego, and Thermo Fisher Scientific, Santa Clara, CA, USA). Can we identify novel variants associated with polycystic ovary syndrome (PCOS) by leveraging the unique population history of Northern Europe? We then ran the colocalization analysis for those eQTL catalogue traits that had at least one cis-QTL within this region with P < 1106. The Helsinki-Uusimaa Region is at the heart of Northern Europe, more precisely in the very south of Finland and it has some 230 km of Baltic Sea coastline. Despite the high prevalence of the syndrome, the origins of PCOS remain unknown. Adaman Irrigation Water Delivery District #36 4. Section 3 Objectives of the District [A] Consolidated Irrigation District No. We thank all FinnGen and EstBB participants for offering us the valuable resources. We further assessed the robustness of our PCOS definition by comparing the effects sizes between the lead variants in the replicated loci presented in the non-NIH Rotterdam criteria (Day et al., 2018) to our association results.
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